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2-Oxoglutarate Dehydrogenase Complex (-Ketoglutarate Dehydrogenase Complex): 2-Oxoglutarate (commonly called -ketoglutarate) is oxidatively decarboxylated to succinyl-CoA by the 2-oxoglutarate dehydrogenase complex, OGDC

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Nature (2017) 548(7666):22833

This mitochondrial protection is achieved through its interaction with Nrf2, as demonstrated by the suppression of these protective effects upon the silencing of this protein using siRNA

It maintains redox balance and helps neutralize cellular stress that accumulates with age

Dynamic liquid biopsy components as predictive and prognostic biomarkers in colorectal cancer