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Compared with the normal feeding model, the kidney inflammation genes such as Emr1, Nos2, and Tnfa were downregulated, and the degree of basophil aggregation was lower in the MR model

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206,209,210,211,212 DN preferentially targets sensory and autonomic axons, with motor axons affected to a lesser extent

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This study also found that elevated GPX4 expression promoted PHC activity, and silenced GPX4 expression achieved contrary results, again validating the regulatory role of GPX4 on PHC progression

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