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"Finally, we are concerned that intranasal nalmefene has not been adequately studied for effectiveness in the actual setting and patient population: for patients with severe opioid intoxication in the out-of-hospital environment

All subjects in cohort 9 maintained exposure throughout the dosing phase but became ADA positive by the end of the study

Before acquisition training started, participants were familiarised with the room pictures, by showing them first simultaneously and then consecutively in random order, until all rooms had been shown twice
