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Striatal vulnerability in huntingtons disease: neuroprotection versus neurotoxicity

The IL-17 secreted by these cells binds to IL-17 receptors (IL-17Rs) expressed in midbrain neurons, inducing neuronal death through the upregulation of NF-B and downstream signaling pathways, as demonstrated in human iPSC-derived neuronal models

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Acknowledgements The authors wish to thank the study participants in the BBC, the nursing staff at labor and delivery of the Boston Medical Center, as well as the field team for their contributions to the Boston Birth Cohort