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For Part B coverage, the injection must satisfy the following criteria: You must have a qualifying diagnosis (for example, pernicious anemia) Your provider must document the medical necessity The injection must be administered in an approved outpatient setting It is important to note that you may still be liable for your Part B deductible and 20% coinsurance, unless you have Medigap (supplemental insurance) to assist with out-of-pocket expenses

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Most commercial payers don't require NDC on professional CMS-1500 claims

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The NCI SEER CanMED database classifies J1453 under the major drug class Antiemetic, minor class Substance P/Neurokinin 1, with an FDA approval year of 2008