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The high GH levels, together with the often severe IGF-1 deficiency, will lead to a severe catabolic state, including significant lipolysis and proteolysis, comparable to extended fasting during a hunger strike, for instance [26]

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The second line of antioxidant defense is represented by diet-derived antioxidants, including vitamins C and E, carotenoids, and flavonoids

In vitro qRT-PCR results confirm the up-regulation of 4 genes and the downregulation of 9 genes in A549 and H1650 cells

3.4 Immune cell dysregulation Immune cells, including macrophages, neutrophils, T cells, and B cells, play a dual role in ARDS pathogenesis