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glutathione cancer stem cell Utilizing glutathione-triggered nanoparticles to enhance chemotherapy of lung by reprograming the tumor microenvironment Frontiers | Glutathione-responsive and -exhausting

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Xie Z, Zhao S, Chang S, McQueen T, Andreeff M

glutathione cancer stem cell Utilizing glutathione-triggered nanoparticles to enhance chemotherapy of lung by reprograming the tumor microenvironment Frontiers | Glutathione-responsive and -exhausting

Control mice were treated with 0.85% saline in water

glutathione cancer stem cell Utilizing glutathione-triggered nanoparticles to enhance chemotherapy of lung by reprograming the tumor microenvironment Frontiers | Glutathione-responsive and -exhausting

Moreover, MRP-1 gene silencing results in cellular GSSG accumulation and cell death 33

glutathione cancer stem cell Utilizing glutathione-triggered nanoparticles to enhance chemotherapy of lung by reprograming the tumor microenvironment Frontiers | Glutathione-responsive and -exhausting

1 Glutamine is utilized in a number of vital functions, including protein synthesis and production of the nucleotide units that make up DNA and RNA

glutathione cancer stem cell Utilizing glutathione-triggered nanoparticles to enhance chemotherapy of lung by reprograming the tumor microenvironment Frontiers | Glutathione-responsive and -exhausting

Animals were allowed food and water ad libitum

glutathione cancer stem cell Utilizing glutathione-triggered nanoparticles to enhance chemotherapy of lung by reprograming the tumor microenvironment Frontiers | Glutathione-responsive and -exhausting

We found that glycolysis, the TCA cycle, and oxidative phosphorylation pathways were all significantly suppressed in our RNA-seq dataset

glutathione cancer stem cell Utilizing glutathione-triggered nanoparticles to enhance chemotherapy of lung by reprograming the tumor microenvironment Frontiers | Glutathione-responsive and -exhausting

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