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A clinical hierarchy: dont stack until youve earned the right to stack Before we even talk combinations, an evidence-led clinic typically wants these foundations in place: Diagnosis clarity: Obesity phenotype, insulin resistance, prediabetes/T2D, dyslipidemia, sleep apnea risk, NAFLD risk Baseline labs: A1c, fasting glucose/insulin (or at least glucose), lipids, CMP, CBC

Taken together, menstrual-cycle-related variations in lipid metabolism appear physiologically consistent but modest in magnitude, and are substantially shaped by metabolic status, lifestyle, and methodological considerations

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Woo HD, Kim J (2013b) Dietary flavonoid intake and risk of stomach and colorectal cancer