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Results Deficiency of USP7 impairs human terminal erythroid differentiation To explore the roles of deubiquitylases during erythropoiesis, we first analyzed the expression patterns of deubiquitylases in human erythroblasts at different stages of differentiation from our RNA-sequencing data.2 Figure 1A shows the expression patterns of USP family members and reveals that the expression levels of USP7 are significantly increased during erythropoiesis

doi: 10.1016/j.mad.2024.111995 [DOI] [PubMed] [Google Scholar] 62.Domaszewska-Szostek A, Puzianowska-Kunicka M, Kuryowicz A

Targeting the antioxidant defense mechanisms of cancer cells has emerged as a promising therapeutic strategy

In this context, HDAC inhibition was identified as a critical enhancer of SFNs impact, with distinct histone acetylation responses differentiating SFN and TSA treatments