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Non-human primate models In non-human primates (NHPs), infection with SARS-CoV, MERS-CoV or SARS-CoV-2 results in viral spread to multiple tissues, including lungs 121,122,123

After that, LV-GPX1 was injected into the PT mice, and the Western blotting results showed that LV-GPX1 also effectively infected the cerebral infarction (Fig

We first evaluated the lifespan of the C32E8.9 OE strain compared to controls with the same genetic background

Unlike native IGF-1, this analog features a 13-amino acid N-terminal extension and an arginine substitution at position 3, conferring reduced affinity for insulin-like growth factor binding proteins (IGFBPs) and thus increased biological activity across multiple experimental models

However, under certain conditions, monocytes accumulate in the intestines and differentiate into highly sensitive pro-inflammatory macrophages