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Disturbance of gut barrier function has critical consequences beyond the intestinal system

(EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)) (January 2014)

LPS-induced miR-21-3p overexpression increased the protein and mRNA levels of the inflammatory cytokines monocyte chemoattractant protein-1 (MCP-1) and IL-6 in RPE cells while elevating apoptosis, caspase-3 activity, and levels of cleaved caspase-3 and poly-(ADP-ribose) polymerase proteins, which exacerbate inflammatory responses and apoptosis

Characteristics of Reactive Oxygen Species ROS are oxygen-containing compounds that are highly reactive free radicals, or compounds that are readily converted to these oxygen-free radicals in the cell

Cyclophosphamide induced stomach and duodenal lesions as a NOsystem disturbance in rats: LNAME, Larginine, stable gastric pentadecapeptide BPC 157
