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Hoyles L, Fernndez-Real JM, Federici M, Serino M, Abbott J, Charpentier J

Glutathione may play a role in the antioxidant properties of BPC-157.41 Additionally, BPC-157 is present in most tissues, where it can bind reactive free radicals and inactivate them at crucial positions not reachable by other antioxidants.44 BPC-157 is involved with maintaining endothelial integrity.13,14,33 BPC-157 also acts as a free radical scavenger, counteracts free radicalinduced lesions, and normalizes nitric oxide levels in tissues and during ischemia and reperfusion.31,42 BPC-157s many pleiotropic benefits involve the VEGFR2 and growth hormone receptors as well as distinctive pathways, including VEGFR2-AKT-eNOS, ERK1/2, FAK-paxillin, FoxO3a, p-AKT, p-mTOR and p-GSK-3.16,43-45 VEGFR2-AKT-eNOS (vascular endothelial growth factor receptor 2 and AKTendothelial nitric oxide synthase): Crucial for endothelial function and nitric oxide production, which support blood vessel health and repair

Berman E, Raymond V, Gee T, Kempin SJ, Gulati S, Andreeff M , Kolitz J, Gabrilove J, Heller G, Young CW, et al

BMC Syst Biol 7:103 Liu B, Teschemacher AG, Kasparov S (2017) Astroglia as a cellular target for neuroprotection and treatment of neuro-psychiatric disorders