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An indirect evaluation can be made by measuring the levels of vitamin K-dependent coagulation factors, which are below 50% in the presence of vitamin deficiency

The effects of vitamin D supplementation on metabolic profiles and gene expression of insulin and lipid metabolism in infertile polycystic ovary syndrome candidates for in vitro fertilization

It also increases ovulation and pregnancy rate with fewer side effects such as ovarian hyperstimulation syndrome, commonly seen with other medications

Interestingly, a specific GPX1 polymorphism resulting in a proline-to-leucine transition at position 198 (Pro198Leu) is associated with a reduction in GPx1 activity and found to be more prevalent in Keshan patients

We also acknowledge ANR and Inserm Transfert for the ANR-20-CE-CE14-0028-01 and CoPoC MAT-PI-17493-A-04 grants to R.J.A

Furthermore, the limitations and the present problems are also highlighted in this review