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The pathogenesis of AD is multifactorial, involving the accumulation of amyloidbeta (A) plaques, neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau protein, oxidative stress, and chronic neuroinflammation (GarcaMorales et al

Furthermore, the combination of metformin with 2-deoxyglucose has demonstrated remarkable efficacy in promoting necrotic cell death in glioma cells (38)

These include, for example, the Patient Health Questionnaire9 [213], the Generalized Anxiety Disorder7 Scale [214], the Insomnia Severity Index [216], and PatientReported Outcomes Measurement Information System from National Institutes of Health

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[DOI] [PubMed] [Google Scholar] 52.Peppin JF, Pappagallo M

Several studies indicate that acupuncture alleviates various BIPN symptoms, particularly numbness, tingling, cold sensitivity, and discomfort in the hands and feet
