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For instance, combining L-carnitine with Coenzyme Q10 (CoQ10) creates a powerful synergistic effect

However, the level of pain can vary from person to person, and many individuals find the discomfort to be tolerable

Hathcock JN, Shao A

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The inclusion criteria were as follows: (1) age between 3 months and 20 years, (2) diagnosed with refractory epilepsy, having persistent seizures even after administration of two or more ASMs, (3) history of seizures within 2 weeks before the study, (4) baseline seizure frequency of more than 2 times per month Patients with a broad spectrum of seizure frequency was included to reflect the clinical heterogeneity of refractory epilepsy

Matthew L Dove, Preeti Jaggi, Michael Kelleman, Mayssa Abuali, Jocelyn Y Ang, Wassim Ballan, Sanmit K Basu, M Jay Campbell, Sathish M Chikkabyrappa, Nadine F Choueiter, Katharine N Clouser, Daniel Corwin, Amy Edwards, Shira J Gertz, Rod Ghassemzadeh, Rima J Jarrah, Sophie E Katz, Stacie M Knutson, Joseph D Kuebler, Jennifer Lighter, Christine Mikesell, Kanokporn Mongkolrattanothai, Ted Morton, Natasha A Nakra, Rosemary Olivero, Christina M Osborne, Laurie E Panesar, Sarah Parsons, Rupal M Patel, Jennifer Schuette, Deepika Thacker, Adriana H Tremoulet, Navjyot K Vidwan, Matthew E Oster