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2 Clinical evidence for natural supplements 2.1 Vitamins and minerals Researchers have been a lot of interest in the clinical evidence linking vitamins and minerals, especially vitamin D, calcium, and selenium, to the treatment and prevention of breast cancer ( Patients with breast cancer, whether they utilise aromatase inhibitors or are undergoing chemotherapeutic, ovarian failure, which promotes bone loss and increases the risk of fractures, must have adequate calcium and vitamin D levels checked regularly to keep their bones healthy ( 2.2 Phytochemicals 2.2.1 Curcumin Curcumin, the principal physiologically active polyphenolic substance in Curcuma longa (turmeric) ( Despite the small sample sizes and dosages used in these clinical trials, the mounting evidence suggests that oral curcumin is well-tolerated, decreases markers of systemic inflammation, protects against mucositis caused by chemotherapy, and alleviates pain in the joints in patients taking aromatase inhibitors ( ) for improved bioefficacy

Nevertheless, TMAO formation from diet-gut microbiota-host interplay might be underestimated by observing fasting plasma TMAO levels because the kidney excretes TMAO efficiently to lower its blood levels [11]