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People with pernicious anemia, may benefit from sublingual B12 as they lack intrinsic factor and have a lot of trouble absorbing B12 through their digestive system (Ankar, 2020)

[5] Similarly, individuals who have undergone gastrointestinal surgery particularly gastric bypass, gastrectomy, or ileal resectionoften have impaired B12 absorption and require supplementation

Caffeine and green tea extract produce mild metabolism effects compared to prescription medications