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Mol Biol Rep 51(1):809 Rawani NS et al (2024) The underlying neurobiological mechanisms of psychosis: focus on neurotransmission dysregulation, neuroinflammation, oxidative stress, and mitochondrial dysfunction

DNA (deoxyribonucleic acid) a molecule that contains our genetic information

Another crucial factor is the usage rate

This view was reinforced by the discovery of McCord and Fridovich (1969), who identified the first protective enzyme against free radicals, superoxide dismutase (SOD)

-Glutamylcysteine ligase expression is subject to regulation by Nrf2, a transcription factor that regulates a wide array of antioxidant responsive element (ARE)-driven genes in various cell types, and thus plays a central role in cellular antioxidant defenses (Jaiswal, 2004

However, selenium should not be routinely supplemented in non-deficient individuals [55, 63], in particular because chronic excess may lead to toxicity (selenosis)