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JAMA 288(3): 321333 (2002)

Modified DPP-4 can not only mask the enzymatic hydrolysis site of DPP-4 but also bind closely with albumin to reduce renal excretion and prolong the half-life

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FDA regards contractors as extensions of the manufacturer. 16 Records Requests In addition to the inspection-based warning letters, the agency utilized its authority under 704(a)(4) to compel companies to share information in advance of or in lieu of an on-site inspection

Funding This study was supported by National Science and Technology Major Projects for Major New Drugs Innovation and Development (No