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Cancer-related fatigue (CRF) in breast cancer survivors is a distressing and persistent sense of physical, emotional, and cognitive exhaustion related to cancer or its treatment, disproportionate to activity level and not relieved by rest [1]

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This is consistent with previous of reports of context-dependent action of coregulators at AR target genes, where they preferentially interact with other components of the AR transcriptional complex to control aspects of cell biology and stages of CaP progression [75, 76]