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Supplementary Materials Data Availability Statement The data generated and analyzed during the current study are available from the corresponding author on reasonable request.

Berberine may interact with antidiabetic medications, anticoagulants, and drugs metabolised by CYP450 enzymes

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It is essential for the initial transport of activated long-chain fatty acids across the mitochondrial membrane via the CPT system, thus governing the substrate flux available for both -oxidation and subsequent ketogenesis

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