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The two-hit vascular hypothesis of Alzheimer's disease proposes that BBB dysfunction allows neurotoxins to enter the brain parenchyma, which in turn leads to neuroinflammation[43]
A summary of the MS parameters is shown in Table S1
The following antibodies were purchased from Cell Signaling Technology: Met (25H2) mouse mAb, phospho-Met (Tyr1234/1235) (D26) XP rabbit mAb, Akt (11E7) rabbit mAb, phospho-Akt (Ser473) (D9E) XP rabbit mAb, Erk1/2 (137F5) rabbit mAb, phospho-Erk1/2 (Thr202/Tyr204) (D13.14.4E) XP rabbit mAb, Gab1 rabbit mAb, phospho-Gab1 (Tyr 627) (C32H2) rabbit mAb and phospho-EGFR (Tyr 1068) rabbit polyclonal Ab
If you accept the bioavailability uncertainty, these are the budget options
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