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(10) Also excluded were those who had received liver function-enhancing medications, antibiotics, choleretic agents, antioxidants, or dietary supplements within 14 days of the first dose of the investigational product, or who did not agree to abstain from such medications from 14 days to the end of the study, (11) and those who had received drugs that induce or inhibit drug metabolizing enzymes, such as barbiturates, within 30 days of the first dose of the investigational product, or who did not agree to abstain from such drugs from 30 days to the end of the study

Based on ligand specificity and satisfactory conformational changes, YliB was carefully chosen as a ligand-sensing domain for the development of a nanosensor for monitoring GSH in vitro and in vivo

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Furthermore, interactions of brain interstitial A with microglia [87, 88] and exposure to transition metals [81,82,83] also contribute to oxidative stress in neurons

5 min high speed (12,000 g ) centrifugation

doi: 10.1016/j.cmet.2024.01.005 66 GruossoTGigouxMManemVSKBertosNZuoDPerlitchIet al