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We replicated both of these findings in human lung fibroblasts, which are the major interstitial cells that maintain tissue structural integrity by sculpting the connective tissue
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doi: 10.1111/apt.14384
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Understanding how it actually works at a biological level, not just what it is claimed to do, is the foundation for making any responsible clinical decision about whether it belongs in a protocol
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Thus, both intrinsic and extrinsic factors play roles in urate production
Moreover, we found that TGFb ligand treatment led to an increase in SNCA expression in our PD cell model, and aSyn-overexpression led to an up-regulation of TGFB1 , TGFB2 , SMAD2 , and SMAD3 in LUHMES cells
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These synthetic type smooth muscle cells, characterized by their high expression of -smooth muscle actin, suggest that this marker may be valuable for diagnosing IC/PBS (Lutgendorf et al., 2002)
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