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Duloxetine Evidence from preclinical [58, 59] and clinical studies [4] suggests that duloxetine, an antidepressant drug acting as a serotonin-noradrenaline reuptake inhibitor (SNRI), may be effective in the prevention of CIPN without reducing the antitumor activity of oxaliplatin [49]

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Neurologic and cognitive concerns (e.g., migraines) and neurodevelopmental symptoms: Findings are mixed across studies and effect sizes are generally small, so we interpret results cautiously and prioritize whole-person assessment over single-gene conclusions