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Furthermore, if the toxins are not properly bound in the gut, they undergo enterohepatic recirculationmeaning they are reabsorbed through the intestinal wall and sent back to the liver, creating an endless loop of internal toxicity

Importantly, matrine also downregulated the protein levels of Vimentin, N-cadherin, MMP2, and MMP9, and upregulated E-cadherin, indicating that matrine inhibits GBC cell invasion and migration at both the transcriptional and translational levels

In particular, GRP content decreased with time in the MRS medium (supports the growth of lactobacilli and others) containing 0.5 mM GRP