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doi: 10.1016/j.molcel.2014.03.003

In stressful situations, the activation of KORs mediates dysphoric and anxiety-inducing effects, which are primarily characterized by a significant reduction in dopamine release in brain regions associated with reward

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However, it is important to recognise that the relative contribution of each compound is far more complex and that additive and synergistic effects cannot be ruled out

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