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-Glutamylcysteine is a GPx1 cofactor that detoxifies H 2 O 2 To decipher how -glutamylcysteine detoxified ROS but otherwise avoiding the influence of cytosolic GCL, we expressed a silent mutant mito GCL form ( mito GCL (mut)) refractory to the action of a small hairpin RNA against GCL (shGCL) 5 , in HEK293T cells (Fig

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[DOI] [PMC free article] [PubMed] [Google Scholar] 61.Silva C., Andrade N., Rodrigues I., Ferreira A.C., Soares M.L., Martel F

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