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[DOI] [PMC free article] [PubMed] [Google Scholar] 120.Medici V., Sarode G.V., Napoli E., et al
21 December 2018

Peer review Peer review information Nature Communications thanks Brady Atwood, Kristen Pleil and the other, anonymous, reviewer(s) for their contribution to the peer review of this work
30 The altered NP cell phenotype can maintain the catabolic environment during disc degeneration 31 and has shown to be responsible for the drop in local pH mediated by, among others, acidsensing ion channels (ASICs) 32 that in turn causes IVD cell loss and ECM breakdown
& Kim, T.-Y
However, less appreciated is the fact that inherent defects in brain energy metabolism, whether through mutations in genes encoding mitochondrial proteins or metabolic substrates and enzymes constituting major biochemical pathways 5,9 , redox instability 10 or epigenetic changes 11 , can independently precipitate seizures