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Unlike orally delivered chelators, which must survive harsh GI conditions and extensive hepatic first-pass effect before reaching systemic circulation, IN drugs only need to cross the nasal epithelium or can directly access the brain through neuronal pathways
10.1016/j.ijpharm.2009.12.031 72 ThiyagarajanD.HuckB.NothdurftB.KochM.RudolphD.RutschmannM.et al (2021)

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Bioactive compounds of the Mediterranean Diet as nutritional support to fight neurodegenerative disease

The liver is involved in homeostasis of nutrients like B12, and both the liver and kidney store and excrete B12