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Unlike orally delivered chelators, which must survive harsh GI conditions and extensive hepatic first-pass effect before reaching systemic circulation, IN drugs only need to cross the nasal epithelium or can directly access the brain through neuronal pathways

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10.1016/j.ijpharm.2009.12.031 72 ThiyagarajanD.HuckB.NothdurftB.KochM.RudolphD.RutschmannM.et al (2021)

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The liver is involved in homeostasis of nutrients like B12, and both the liver and kidney store and excrete B12

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