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Patients with HCV genotype 1, 2, 4, or 6 were randomly assigned in a 5:1 ratio to receive the nucleotide polymerase inhibitor sofosbuvir and the NS5A inhibitor velpatasvir in a once-daily, fixed-dose combination tablet or matching placebo for 12 weeks

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They are also essential in intracellular signalling mechanisms [11, 24], which regulate cell polarity, differentiation, growth and migration [25]

Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication

Los quelantes de hierro disminuyen la toxicidad producida por el depsito masivo de hierro en pacientes politransfundidos141, aunque trabajos recientes cuestionan su capacidad nefroprotectora en el FRA inducido por hemoglobina142