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Biguanides inhibit the mitochondrial respiratory chain in the liver, activating the AMPK pathway, enhancing insulin sensitivity, suppressing gluconeogenesis, and reducing both hepatic glucose output as well as glucose entry into the circulation from the intestines [109,110,111,112]

The findings indicate that quercetin significantly reduced oxidative damage, reduced inflammatory markers, preserved neuronal integrity, and improved social and cognitive behaviors

doi: 10.1371/journal.pone.0045079

Sanz AB, Sanchez-Nio MD, Ramos AM, Moreno JA, Santamaria B, Ruiz-Ortega M, et al

Because cortisol is an important regulator of redox homeostasis, reduced cortisol availability or altered glucocorticoid signaling may weaken anti-inflammatory and antioxidant defenses, thereby contributing to persistent oxidative stress
