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The intracellular environment in macrophages has been strongly associated with the induction of metabolic indolence and antibiotic tolerance 7,8,9,10,11

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The presence of circulating exosomal EGFRvIII variants correlated with poor outcomes (130)
For instance, some researchers suggest that RLS is caused by problems with the brain chemical dopamine, while others suggest that its related to poor circulation

Farfariello V, et al

ACS Nano 16 , 65156526 (2022)