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[6] During muscle contraction: H 2 O + ATP H + + ADP + P i (Mg 2+ assisted, utilization of ATP for muscle contraction by ATPase) H + + ADP + CP ATP + Creatine (Mg 2+ assisted, catalyzed by creatine kinase, ATP is used again in the above reaction for continued muscle contraction) 2 ADP ATP + AMP (catalyzed by adenylate kinase/myokinase when CP is depleted, ATP is again used for muscle contraction) Muscle at rest: ATP + Creatine H + + ADP + CP (Mg 2+ assisted, catalyzed by creatine kinase) ADP + P i ATP (during anaerobic glycolysis and oxidative phosphorylation) AMP can dephosphorylate to adenosine and diffuse out of the cell

Obes Rev (2019) 20:114858

It was approved by the Food and Drug Administration in March 2024 and marks the first medication approved to treat NASH

and Wang, X

Nat Rev Cancer (2004) 4(7):55161

Authors contributions VO, SN, OE, CA and FZ conducted a review of the literature and contributed to conception and design and wrote the first draft the review