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Generally the three superfamilies differ mostly in structure and sequence as only the cytosolic and the mitochondrial superfamily have a thiorexin like domain in which the glutathione binding site (G-site) is located Oakley A.,2011

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Reports indicate puerarin mitigated reactive oxygen species (ROS)induced tissue damage, subsequently enhancing antitumor efficacy [116]

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Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer