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NPR Shots

CB-839 is a small molecule inhibitor of kidney type glutaminase (GLS)

Therefore, studies addressing the effect of treatments in different groups of patients are needed

All methods utilized a Waters ACQUITY ultra-performance liquid chromatography (UPLC) and a Thermo Scientific Q-Exactive high resolution/accurate mass spectrometer interfaced with a heated electrospray ionization (HESI-II) source and Orbitrap mass analyzer operated at 35,000 mass resolution

The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic

The therapeutic window for inhibiting GGT as a cancer therapy is potentially large, as sustained inhibition of GGT activity did not induce any overt toxicities