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doi: 10.1016/j.pharmthera.2020.107709 69 SempowskiGDRozenblitJSmithTJPhippsRP

doi: 10.1016/j.mtbio.2022.100370 97 HwangSJKimY-WParkYLeeH-JKimK-W

Richardson PG, Jacobus SJ, Weller EA, Hassoun H, Lonial S, Raje NS, Medvedova E, McCarthy PL, Libby EN, Voorhees PM, Orlowski RZ , Anderson LD, Zonder JA, Milner CP, Gasparetto C, Agha ME, Khan AM, Hurd DD, Gowin K, Kamble RT, Jagannath S, Nathwani N, Alsina M, Cornell RF, Hashmi H, Campagnaro EL, Andreescu AC, Gentile T, Liedtke M, Godby KN, Cohen AD, Openshaw TH, Pasquini MC, Giralt SA, Kaufman JL, Yee AJ, Scott E, Torka P, Foley A, Fulciniti M, Hebert K, Samur MK, Masone K, Maglio ME, Zeytoonjian AA, Nadeem O, Schlossman RL, Laubach JP, Paba-Prada C, Ghobrial IM, Perrot A, Moreau P, Avet-Loiseau H, Attal M, Anderson KC, Munshi NC, Investigators D

Methylated amino acids in the proteins of bacterial and mammalian cells

That binding triggers a rise in cyclic AMP, which then activates a signaling chain that drives melanin production and a range of protective cellular responses: Eumelanin synthesis: MC1R activation stimulates melanocytes to produce eumelanin, the darker, more photoprotective form of melanin