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These functional improvements were accompanied by normalization of heart failure biomarkers including N-terminal pro-brain natriuretic peptide and pro-inflammatory cytokines (TNF-, IL-6, C-reactive protein)

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NA prevents Pellagra (Prousky et al., 2011) and has positive effects on the regulation of lipids (total cholesterol, triglycerides and LDL) (Guille et al., 2008) (Tabla 2)

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"The iTind Temporarily Implanted Nitinol Device for the Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia: A Multicenter, Randomized, Controlled Trial"

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The presence of helix-based docking across the Rb family led us to search for the conserved sequence motif, which we identified by aligning 682 C-terminal sequences of metazoan Rb family members (Medina et al., 2016) and generating a consensus sequence motif (Figure 4E)

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