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First, the paramount hurdle of Delivery and Safety must be overcome by engineering sophisticated, cell-specific vectors capable of safely and efficiently ferrying gene-editing machinery to precise cellular targets within the living body, a task particularly formidable for ubiquitous immune cells such as antigen-presenting cells

doi: 10.1182/blood.2022015403

The generation of the -hydroxy ethyl radical may also lead to inactivation of the enzyme

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