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Partners in crime: beta-cells and autoimmune responses complicit in type 1 diabetes pathogenesis

Very common: more than 1 in 10 treated patients
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Unique role of NADPH oxidase 5 in oxidative stress in human renal proximal tubule cells

In this review we will focus on (a) GSH depletion as a fundamental risk factor for diseases like chronic obstructive pulmonary disease and atherosclerosis (ischemic heart disease and stroke), (b) importance of oxidative stress and antioxidants in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and COVID-19 disease, (c) significance of GSH to counteract persistent damaging inflammation, inflammaging and early (premature) inflammaging associated with cell and tissue damage caused by excessive oxidative stress and lack of adequate antioxidant defenses in younger individuals, and (d) new therapies that include antioxidant defenses restoration

doi: 10.2337/dc11-1582