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We used a pre-clinical controlled cortical impact (CCI) model of TBI to determine whether CAQK might have such an intrinsic activity

Intranasal delivery may produce fewer gastrointestinal side effects due to lower systemic exposure, consistent with findings from intranasal GLP-1 clinical trials

Fritjofsson A, Fall M, Juhlin R et al: Treatment of ulcer and nonulcer interstitial cystitis with sodium pentosanpolysulfate: A multicenter trial

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It is important to note that retatrutide has not yet received marketing authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA), and it remains under clinical investigation

To reconcile the discrepancy between the measurements and the solubility-based model predictions, previous studies have hypothesized that surface adsorption can be a predominant mechanism for water uptake of highly viscous SOMs (e.g., as characterized by particle rebound) 14,15