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3 Rasburicase, a recombinant form of the enzyme urate oxidase, is a drug formulated to treat hyperuricemia, which can be caused by tumor lysis syndrome (TLS)

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The [6,6- 2 H 2 ]-labeled glucose (Glc6) is converted by the glycolysis to pyruvate, which quickly exchanges with a lactate pool

9.1 Indirectly regulate immune cells by affecting tumor cells Most immunomodulatory nanoparticles primarily act on tumor cells to indirectly activate anti-tumor immunity, such as by inducing tumor cell death, including ICD, ferroptosis, and pyroptosis