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Bioengineered 13 , 40634075 (2022)

Recent approvals include EGFR monoclonal antibodies (e.g., Necitumumab) [5] and immune checkpoint inhibitors (e.g., Pembrolizumab, Tislelizumab, Sintilimab) [6,7,8], while platinum-immunotherapy combinations have now become the standard first-line treatment for metastatic disease [9, 10]

This region has been subsequently proven to form non-Watson-Crick base pairs: purine pairs between the GA at the 5 base of the stem (in the conserved A/GUGA sequence) and the GA at the 3 base, and pyrimidine pairs flanking these two

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