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For HMOX1 and SRXN1, global cellular GFP intensity was detected as an indicator of their respective expression levels

Remarkably, treatment with CuII(atsm) significantly mitigated neuronal injury in the ALS mouse model (Liddell et al., 2024)

The redox state of GSSG/GSH serves as an important indicator of the redox environment, defined by its redox potential (E GSSG/2GSH = 269.55 log([GSH] 2 /[GSSG]) mV at 25 C and pH 7.0) and its reducing capacity (total GSH concentration)

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In the presence of GSSG, Cys49 and Cys61 that flank helix 2 become glutathionylated as well (Supplementary Fig