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Strikingly, nearly half of all genes related to OXPHOS were upregulated in bones of LCN2-deficient mice, including genes of electron transport chain (ETC) complexes IV (Fig

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doi: 10.1038/s41598-018-32356-8

doi: 10.1093/carcin/5.4.505

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Rods are also highly metabolically active, essential in maintaining tissue oxygen levels in the retina, and greatly outnumber cones ~ 95:5 [6]
