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External factors that contribute to the production of free radicals include smoking, environmental pollutants, radiation, drugs, pesticides, industrial solvents, and ozone (Gven et al

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When it comes to Graves disease, hyperthyroidism can worsen the autoimmunity

While kojic acid is generally considered safer than hydroquinone, pregnant and breastfeeding women should consult their healthcare provider before use

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Endothelial injury generated directly by intracellular viral replication and by ACE2 downregulation, exposing cells to angiotensin II in the absence of the modulator effects of angiotensin 17 (270, 271), and vascular chronic inflammation promoting the development of tissue macrophages overloaded by cholesterol (foam cells), both increase the possibility of acquiring a severe COVID-19 infection (209, 258, 259, 272, 273)