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I.NakayaM.OkuyamaS.SawamotoA.NakajimaM

P., Schulman, B
Sustained high levels of parathyroid hormone, as seen in hyperparathyroidism, stimulate osteoclasts and lead to net bone loss and hypercalcemia

Oral administration creates slower absorption with sustained but lower peak concentrations due to first-pass metabolism, which may reduce the need for daily dosing as the compound remains bioavailable for extended periods

10.14336/ad.2021.0929 23 LvP.2017

This small molecule peptide functions as a selective nicotinamide N-methyltransferase (NNMT) inhibitor, targeting cellular metabolism at its source
