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or Have had optimal treatment with allopurinol, however, renal impairment means that probenecid cannot be added or is likely to be ineffective Patients who have had previous Special Authority approval for benzbromarone are also eligible for Special Authority approval for febuxostat (see: Benzbromarone to be discontinued)

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It was shown to have multiple sites of action

Analysis of cultured hippocampal 22q11 deleted mouse neurons shows reduced spine density, smaller mushroom spine heads, and reduced dendritic complexity, suggesting morphological immaturity (Xu et al., 2013)

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