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Description
In Step 1, glyceraldehyde-3-P (RCHO) reacts with the active-site sulfhydryl group of GAPDH to form a thiohemiacetal adduct

however, the negative charge at the C terminus and its long range non-covalent interaction with the N terminal domain protects the protein from losing its native state and committing to fibrillation

You are free to relax, read, or use your device throughout the session

M.WhitnallM.RahmantoY

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