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Dopaminergic neuronal loss and Lewy body formation in the substantia nigra pars compacta are the hallmarks of most PD pathology

ICA-1s may depend on physiological factors such as enzyme activity, plasma protein and bloodcell binding, and gastrointestinal motility 16

Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for proteasome inhibitor-mediated cardioprotection

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